Abstracts overzicht

Benign hematology
Experimental Transplantation and immunology
Hematopoiesis
Leukemias (AML, ALL, CML, MDS)
Lymphoid malignancies (NHL, Hodgkin, CLL, Myeloma), Clinical
Lymphoid malignancies (NHL, Hodgkin, CLL, Myeloma), Experimental
Myeloproliferative neoplasms

Benign hematology

  Titel   1e auteur  
  Hemarthrosis results in an increase in Articular Fibrinolytic activity in Hemophilic Mice   L Nieuwenhuizen  
  Response to desmopressin in hemophilia A patients with low FVIII levels   S.C.M. Stoof  
  Arterial thrombosis in Von Willebrand Disease.   YV Sanders  
  Increasing the dose of rabbit-ATG does not lead to a higher response rate in the first line treatment of severe aplastic anemia.   CJM Halkes  
  Voriconazole concentrations are significantly influenced by inflammatory reactions   MJP van Wanrooy  
  Uniparental isodisomy and progressive clonal selection: a common mechanism causing late onset beta-thalassemia Major?   C.L. Harteveld  

Experimental Transplantation and immunology

  Titel   1e auteur  
  Treatment of steroid resistant grade II to IV acute GVHD by infusion of mesenchymal stroma cells expanded with human plasma and platelet lysate - a phase I/II study   CM Mansilla Puerta  
  Apoptotic blebs from leukemic cells as a source of tumor associated antigen for monocyte-derived dendritic cell loading      J.M. Ruben  
  Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host-disease upon cancer treatment with allogeneic stem cell transplantation   W.A. Hobo  
  Collateral Damage of Non-hematopoietic Tissue by Hematopoiesis-specific T Cells Results in GvHD During an Ongoing Profound GvL Reaction   B van der Zouwen  
  DEVELOPMENT OF ANTIBODY RESPONSES AGAINST H-Y ANTIGENS AND THEIR X-VARIANTS AFTER ALLOGENEIC HEMATOPOEIETIC STEM CELL TRANSPLANTATION AND DONOR LYMPHOCYTE INFUSION     JC van der Griendt  
  Generation of allo-HLA restricted T-cells with potent B-cell reactivity using MHC tetramer pull down carries the risk of off-target reactivity   L. Jahn  
  Improved outcome following Intensive Care Unit support within 100 days after allogeneic Haematopoietic Stem Cell Transplant   M. van Vliet  
  Improving human monocyte-derived dendritic cell vaccines by lipid nanoparticle-mediated delivery of PD-L1 and PD-L2 siRNA   W.A. Hobo  
  Multipotent Vδ2-negative γδT-cells after CMV-reactivation in allogeneic stem cell transplantation   W.A. Scheper  
  Pre-clinical evaluation of ex vivo-generated natural killer cells as immunotherapeutic product against acute myeloid leukemia.   J. Cany  
  Rapid identification and expression analysis of minor histocompatibility antigens by whole genome association scanning and microarray gene expression analysis     MJ Pont  
  The Aryl hydrocarbon Receptor antagonist StemRegenin1 promotes expansion of immature hematopoietic progenitors     L Duinhouwer  
  A Good Manufacturing Practice procedure to generate therapeutic numbers of highly pure anti-leukemic virus-specific T-cells   M.M. van Loenen  
  B and T lymphocyte attenuator mediates inhibition of MiHA-specific CD8+ T cells in allogeneic stem cell transplantation patients   WJ Norde  
  Decreased levels of circulating CCR6+CD161hiCD8+ T cells harboring cyclosporine resistance are associated with the development of graft-versus-host disease   AB van der Waart  
  Identification of New Hematopoietic Minor Histocompatibility Antigen UTA2-1; Applicable in Antitumor Immunotherapy.   R. Oostvogels  
  In vivo T-cell depletion using rabbit derived ATG leads to an increased EBV-PTLD risk due to an induced imbalance between B and T-cell recovery which is not seen after horse derived ATG or alemtuzumab   I Jedema  
  Promising efficacy of combined inolimomab and etanercept in severe steroid-refractory acute graft-versus-host disease (aGVHD)   A Liefferink  
  The chemokine receptor CXCR3 is required for the efficient recruitment of bone marrow-resident memory T cells to inflamed tissues   R van der Voort  
  Occurence of T cells specific for the Aspergillus proteins Crf1 and Catalase1 in SCT patients recovering from invasive aspergillosis.   H Jolink  

Hematopoiesis

  Titel   1e auteur  
  ACETYLATION OF C/EBPε IS FUNCTIONALLY IMPORTANT DURING NEUTROPHIL DEVELOPMENT.   M Bartels  
  Erythropoiesis and globin switching in compound Klf1-Bcl11a mutant mice   F. Esteghamat  
  Identification of novel cytokines and chemokines that induce HSC expansion   A. Ocal Sahin  
  Interferon-gamma Impairs The Self-Renewal Of Hematopoietic Stem Cells   A.M. de Bruin  
  Matrix protein βig-h3 function in hematopoietic and stromal cells   S.E. Klamer  
  The extracellular matrix protein Slit3 promotes erythropoiesis.     K. Brussen  
  Central memory CD8 T cells regulate hematopoietic stem cell function   C.I. Brandao  
  Developing thymic regenerative therapy by generating thymic epithelial precursor cells from induced pluripotent stem cells   E Vroegindeweij  
  Polycomb Group Complex 1 Composition determines Hematopoietic Stem Cell fate   V. Radulovic  
  PRC1 complex composition dictates locus-specific polycomb-mediated repression in human stem/progenitor cells   V. van den Boom  
  Regulation of erythrocyte shape through LYN-induced tyrosine phosphorylation and downstream events.   E Ovchynnikova  
  Regulation of membrane complex - cytosceleton interactions in erythrocytes. The role of the Band 3 complexes   E.V. Ovchynnikova  
  The E3 ubiquitin ligase Triad1 prevents chromosomal missegregation by regulating the checkpoint kinase Bub1   D Monteferrario  
  The transcription factor MEIS1 regulates early erythroid and megakaryocytic cell fate   S. Zeddies  

Leukemias (AML, ALL, CML, MDS)

  Titel   1e auteur  
  High miR-212 expression predicts for better survival in cytogenetically and molecularly heterogeneous AML   SMS Sun  
  A hazard based flow cytometric scoring system for the prognosis of myelodysplastic syndromes   C Alhan  
  CEBPα Is a Transcriptional Repressor of T-Cell Related Genes Explaining the Myeloid/T-Lymphoid Features of CEBPα-Silenced AML   E Taskesen  
  Constitutional t(16;21)(p13;q22) as a novel pathogenomic mechanism in a series of three new RUNX1 mutated FPD/AML pedigrees: implications for diagnostics   A. Buijs  
  Exome Sequencing of Late Recurrence T-Cell Acute Lymphoblastic Leukemia in Children Confirms Second Leukemia and Exposes Predisposition Candidate Genes   E Waanders  
  High GATA-2 expression is a poor prognostic marker in pediatric Acute Myeloid Leukemia   M. Luesink  
  MicroRNA Expression Profiling of Hematopoietic and Leukemic Stem Cells in Acute Myeloid Leukemia     D.C. de Leeuw  
  Mutations in TET2 and IDH in patients with acute myeloid leukemia perturb a common epigenetic pathway resulting in decreased 5-hydroxymethylcytosine levels   M.G. Aslanyan  
  Mutations in TET2 and IDH in patients with acute myeloid leukemia perturb a common epigenetic pathway resulting in decreased 5-hydroxymethylcytosine levels   M.G. Aslanyan  
  PCR-based detection of PLZF-RARα  fusion gene in Iranian patients with acute promyelocytic leukemia morphology   Mohammad Araghi  
  Plasma Membrane proteomics on human HSCs/MPPs/LSCs.   F. Bonardi`  
  Prognostic pre-transplant factors in myelodysplastic syndromes primarily treated by allogeneic hematopoietic stem cell transplantation: a retrospective study on behalf of the MDS subcommittee of the Chronic Leukaemia Working Party of the EBMT   E. Cremers  
  Targeting of Acute Myeloid Leukemia (stem) cells by anti-CLEC12A Antibody-Drug-Conjugates and Bispecific CLL-1xCD3 BiTE Antibody   P. Noordhuis  
  The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution   B. Scheijen  
  The role of the class III PI3K Vps34 in regulation of normal and malignant hematopoiesis     R. Polak  
  Therapeutic target identification specific for leukemic stem cells of Acute Myeloid Leukemia   H.J.M.P. Verhagen  
  Towards immunotherapy of acute myeloid leukemia with allogeneic NK cells generated from umbilical cord blood hematopoietic progenitor cells   B. N. Hangalapura  
  miR34-a and POXP1 are involved in a negative feedback loop responding to double-stranded DNA breaks in developing B cells   K Ochodnicka  
  CITED2 Modulates Differentiation and Proliferation of Normal and Leukemic Hematopoietic Stem and Progenitor Cells Downstream of PU.1.     H. Schepers  
  Combination of CD34/CD38 Immunophenotypes and Side Population (SP) reveals the Putative Leukemia Stem Cell/Leukemia Initiating Cell in Acute Myeloid Leukemia   F. Wouters  
  Comparison of high resolution microarray-based genomic profiling and multiplex ligation-dependent probe amplification (MLPA) for the detection of clinically relevant genetic lesions in acute lymphoblastic leukemia   A Simons  
  Gene expression profiling, high-density genome-wide genotyping and copy number analyses of adult acute lymphoblastic leukemia.   M.A. Sanders  
  GFI1 is a direct target of the oncofusion protein AML1-ETO in acute myeloid leukemia   J Israel  
  High class II-associated invariant chain peptide (CLIP) expression on residual leukemic cells is associated with increased relapse risk in acute myeloid leukemia   W van den Ancker  
  Mouse versus human extrinsic cues dictate transformation potential in BCR-ABL/BMI1-induced leukemia in human xenograft models.     P.S Sontakke  
  New multiparameter approach for the identification of leukemic stem cells in acute myeloid leukemia patients.     W Zeijlemaker  
  NF-κB and MCL-1 Are Important Determinants for the Effectiveness of Bortezomib In CD34+ AML Cells   M.C.J. Bosman  
  Sensitivity of Pediatric Acute Leukemia Cells to Bortezomib and Epoxyketone-Based Proteasome Inhibitors: Correlations with Proteasome Subunit Expression   D. Niewerth  
  SNP-based genomic profiling and karyotyping as diagnostic tools for the identification of clinically relevant chromosomal abnormalities in MDS   M-JPL Stevens-Kroef  
  Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies   L.I. Kroeze  
  Heck of a job there, it absloutely helps me out.    

Lymphoid malignancies (NHL, Hodgkin, CLL, Myeloma), Clinical

  Titel   1e auteur  
  Are we on the right track? Incidence, survival and mortality from plasma cell malignancies in the Netherlands in the last two decades: results from a population based study.     S.G.R. Verelst  
  Comparison of screening tools MUST and SNAQ in hematopoietic stem cell transplantation patients: an explorative study.   A van Wegberg  
  Evaluation of a Patient Information Website concerning Long-term Adverse Effects following Hodgkin Lymphoma treatment   GCC Sombroek  
  High Dose (HD-AraC) vs Standard Dose Cytosine Arabinoside (SD-AraC) during Induction and IL-2 vs Observation after Consolidation/Autologous stem cell transplantation in patients with Acute Myelogenous Leukemia (AML): Final report of the AML-12 randomized phase III trial of EORTC and GIMEMA Leukemia Groups on the value of High Dose AraC     R. Willemze  
  Implementation of plerixafor in Dutch leukapheresis departments   R.R.D. Gahar  
  Optimal treatment sequencing in patients with multiple myeloma not eligible for stem cell transplantation: modelling as a solution to questions that trials can’t answer?   M van Agthoven  
  Patient participation during medical encounters in lymphoma cancer; patients’ preferences and needs   I.R. van Bruinessen  
  Persistent fatigue among (long-term) non-Hodgkin lymphoma survivors: results from the longitudinal population-based PROFILES registry in the South of the Netherlands   S. Oerlemans  
  Preliminary Results from a Phase III Trial of Imatinib Versus Imatinib in Combination with Cytarabine in Patients with First Chronic Phase Myeloid Leukemia   N Thielen  
  Quantitative in-vivo monitoring of bone formation in multiple myeloma patients following treatment with bortezomib: a pilot study.   JC Regelink  
  Rituximab as maintenance treatment for follicular lymphoma in daily practice in the Netherlands: A population based study   H.M. Blommestein  
  The direct treatment costs for patients with acute myeloid leukemia     A. Leunis  
  Treatment with Lenalidomide in myelodysplastic syndromes with 5q deletion: results from the Dutch named patient program (NPP)   I Abouyahya  
  Alemtuzumab treatment can affect CD52 positive as well as CD52 negative GPI-deficient Sézary cells allowing long-term disease control.   CJM Halkes  
  Diminished Asparaginase Turnover Due to a Germline Mutation in Cathepsin B   L van der Meer  
  Does 18F-fluorodeoxyglucose Outperform 18F-fluorothymidine When Using Positron Emission Tomography in Predicting Transformation of Indolent Non-Hodgkin’s Lymphoma   M.J. Wondergem  
  Endocrine late sequelae in long-term survivors of childhood non-Hodgkin lymphoma   M van Waas  
  R-DHAP Immuno-Chemotherapy Is An Effective Remission-Induction Treatment for Fludarabine Refractory CLL Patients and Allows the Majority to Proceed to Allogeneic Stem Cell Transplantation. Results of the Planned Interim Analysis of the Dutch-Belgian Prospective Multicenter HOVON88 Trial   M van Gelder  
  The Impact of Prophylactic Fresh Frozen Plasma On Venous Thromboembolism in Adults Treated for Acute Lymphoblastic Leukemia   MN Lauw  

Lymphoid malignancies (NHL, Hodgkin, CLL, Myeloma), Experimental

  Titel   1e auteur  
  The molecular targets of Dasatinib involved in conferring CD40-mediated drug resistance in chronic lymphocytic leukemia   C.R. Geest  
  Bortezomib restores defective apoptosis by upregulation of Noxa in Enteropathy-associated T-cell Lymphoma   LR de Baaij  
  CMV-secific T cell function is not impaired in CLL   G.D. Te Raa  
  Identification of miR-155 targets in Burkitt lymphoma   I. Slezak-Prochazka  
  Induction of TAp73 expression by platinum-based compounds to overcome drug resistance in p53 dysfunctional chronic lymphocytic leukemia   S H Tonino  
  Loss of the tumor suppressor CYLD causes enhanced NF-kappaB and Wnt/b-catenin signaling in multiple myeloma and confers drug resistance   H. van Andel  
  Microenvironment Shields Myeloma from Adoptive Immunotherapy by Cell Adhesion Mediated Immune Resistance (CAM-IR)   S.J. de Haart  
  Molecular dissection of signals provided by activated T cells to CLL cells indicates major role for IL-21 and CD40 in controlling proliferation and chemoresistance   MF Pascutti  
  Multiple HLA class I and II associations in classic Hodgkin lymphoma and EBV status defined subgroups     Kushi Kushekhar  
  The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia   MFM de Rooij  
  The forkhead transcription factor FOXP1 represses human plasma cell differentiation   M van Keimpema  
  Toll-like receptor expression profile of human myeloma derived cell lines   J. Abdi  
  Towards Personalized Medicine Using a Novel Preclinical Model: Identifying Daratumumab as Effective Treatment for Multiple Myeloma   GWJ Groen  
  A High-Risk Survival Signature for Multiple Myeloma   R. Kuiper  
  APRIL is present in the microenvionment of CLL, and affects disease progression in the TCL-1 transgenic mouse model   JG Schot  
  Expression and functional studies of IGF1R tyrosine kinase in Hodgkin lymphoma     L Zheng  
  Expression of c-Met in tumor cells correlates with favorable outcome in classical Hodgkin lymphoma   W.J. Plattel  
  hsTRAIL/Apo2L-Induced Apoptosis in Enteropathy-Associated T-Cell Lymphoma   M. Radersma  
  Identification of a Novel B-CLL Subset Expressing Mutated Stereotypic B-Cell Receptors with Specificity for Yeast Mannan   R Hoogeboom  
  Is there a germinal centre-like and activated B-cell like diffuse large B-cell lymphoma miRNA profile?   JL Robertus  
  Synergistic Action of the Human Inhibitory KIR Antibody IPH2102, and the Human CD38 Antibody Daratumumab to Enhance the Lysis of Primary Multiple Myeloma (MM) Cells in the Bone Marrow Mononuclear Cells (MNCs) from Myeloma Patients.   I.S. Nijhof  

Myeloproliferative neoplasms

  Titel   1e auteur  
  Deep-sequencing investigation into TET2, CBL and KRAS mutations in myeloid malignancies   P. da Silva-Coelho